Professor of Chemistry
Office: HCH 206
SEU Box: 805 e-mail : healy@stedwards.edu
Phone: (512) 448-8467
Education
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University College Cork, Ireland, 1976-1980 B.S. Chemistry.
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University of Texas at Austin, 1980-1984 Ph.D. Chemistry.
Research Interests
The general focus of our research involves the use of molecular modeling to design structure-activity probes for the purpose of elucidating enzymatic activity. Recent targets have included HIV-1 integrase, the c-Kit and src-abl proteins associated with tumor development and certain leukemias, and the metalloproteinases associated with the shedding of chemokine CXCL16. We have also developed in silico characterizations of the mechanism of action of the Mtb alpha-crystallin protein, and models for the heat shock response of Escherichia coli and for the observed suppression of spinocerebellar ataxia by human alphaB-crystallin. A transient, non-obligate oligomer model has also been developed to explain aspects of the etiology of Amyotrophic Lateral Sclerosis or ALS.A more detailed description of this research can be be viewed at the link shown to the right.
Teaching Interests
A full listing of my courses, with syllabi and class materials, can be viewed at the link shown to the right.
Recent Publications
Healy, E.F., Rowland, C. †, Topological Analysis of the Electron Density of Molecules with Bridging Hydrogens to Tackle the Chemical Structure Monolith, European Journal of Inorganic Chemistry 2022, 34, e202200538. doi: https://doi.org/10.1002/ejic.202200538
Healy, E.F., "How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17" Biochem. Biophys. Res. Commun. 2022 593, 52-56. doi 10.1016/j.bbrc.2022.01.038
Healy, E.F., Lilic, M..†, "A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17" Biochem. Biophys. Res. Commun. 2021 573, 158-163. . doi https://doi.org/10.1016/j.bbrc.2021.08.040
Eamonn F Healy,Lisa M. Goering, Charles R. Hauser, and Peter J. King “An immunomodulatory role for the Mtb Acr protein in the formation of the tuberculous granuloma” FEBS Lett.2021, 595, 284-293.doi
10.1002/1873-3468.13998
Eamonn F Healy, "Organic chemistry as representation", Foundations of Chemistry, 2021 23, 59-68.doi: 10.1007/s10698-020-09379-z
Healy, E. F., & Blade, G.† “Tips and Tools for Teaching Organic Synthesis Online” Journal of Chemical Education, 2020 97, 3163–3167.doi: 10.1021/acs.jchemed.0c00473
Healy, Eamonn F., Rafael Flores†, Vincent M. Lynch, and Santiago Toledo. "Protein dynamics of [Cu-Zn] superoxide dismutase (SOD1): How protein motions at the global and local levels impact the reactivity of SOD1." Journal of Inorganic Biochemistry 2020, 210, 111161. doi 10.1016/j.jinorgbio.2020.11116.
Eamonn F. Healy. "Reply to Comment on “Should Organic Chemistry Be Taught as Science?”", Journal of Chemical Education 2020, 97, 1215-1215. doi: 10.1021/acs.jchemed.0c00213.
Eamonn F Healy, Analise Roth-Rodriguez† and Santiago Toledo “A model for gain of function in superoxide dismutase” Biochem. Biophys. Rep. 2020, 21, 100728 doi: 10.1016/j.bbrep.2020.100728.
Eamonn F Healy, Should Organic Chemistry be taught as Science ?, Journal of Chemical Education, 2019 , 96, 10, 2069-2071 doi: 10.1021/acs.jchemed.9b00122 .
Eamonn F Healy, Luis Cervantes†, Barret Nabona†, Jacob Williams†, A unified mechanism for plant polyketide biosynthesis derived from in silico modeling, Biochemical and Biophysical Research Communications, 2018,497, 1123-1128. . doi: 10.1016/j.bbrc.2018.02.190
E.F. Healy, “Visualizing the molecular wave function in sigma-coordinated complexes”, Computational and Theoretical Chemistry, ,2018, 1125, 128-132. doi:10.1016/j.comptc.2018.01.010 [for an account see Science Trends]
† student author
A complete list of publications is also available, with the full text for many of these articles available for download at ResearchGate.
Recent Professional Presentations
Healy, E. F., 2019 A mechanism for coupled gain of structure and loss of function in amyotrophic lateral sclerosis.12th EBSA 10th ICBP-IUPAP Congress Madrid, Spain, July EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (Vol. 48, pp. S143-S143). 233 SPRING ST, NEW YORK, NY 10013 USA: SPRINGER.
Healy, E.F., 2017 A Prion-like mechanism in Amyotrophic Lateral Sclerosis. 19th International Union of Pure and Applied Biophysics (IUPAB) and 11th European Biophysical Societies' Association (EBSA) Congress Edinburgh, Scotland, July EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (Vol. 46, pp. S217-S217). 233 SPRING ST, NEW YORK, NY 10013 USA: SPRINGER.SPRINGER.
Cervantes, L*., & Healy, E. (2017, April). Protein dynamics in Superoxide Dismutase (SOD1). In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 253). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
"Structural Ontology and Chemical Epistemology: The case of the pi-complex" Eamonn F Healy, presented at the International Society for the Philosophy of Chemistry - Summer Symposium , Boca Raton, 2016.
PAPER HIST 22 , "Between two stools: Pauling, Mulliken, and Michael J. S. Dewar" Eamonn F Healy, presented at the 251st ACS National Meeting & Exposition, San Diego, Spring, 2016. [for an account see C&E News]
Cienega, L*., & Healy, E. F. (2014, March). Rational design for matrix metalloproteinase (MMP-1). In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 247). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Bui, A.*, & Healy, E. F. (2014, March). Modeling the conformational flexibility of resveratrol. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 247). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Little, C.*, & Healy, E. (2013, April). Model for small heat shock protein inhibition of polyglutamine aggregation. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 245). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Petty, C. N.*, Healy, E. F., & King, P. (2013, April). Resveratrol and resveratrol derivatives as class IA PI3K inhibitors. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 245). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Paper COMP 193 “Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl ”,Eamonn F Healy, presented at the 244th National Meeting of the American Chemical Society in Philadelpha, Fall 2012.
Paper CHED 360 “Acetylenic inhibitors of ADAM10 and ADAM17: In silico analysis of potency and selectivity”, Pablo G Romano *, Moises Mejia* , Eamonn F Healy, presented at the 243rd National Meeting of the American Chemical Society in San Diego, Spring 2012.
Presenters are underlined; undergraduate student authors are noted by asterisks.
