department of chemistry and biochemistry
 

CHEM4341 : Forensic Chemistry

 

Dr. Eamonn F. Healy

 

Curriculum :


Forensic Journals:

Forensic Links:

Analaytical Chemistry Links:

  • Resources for Analytical Chemistry students

TOPIC: Evidence and Bayesian Probability

LECTURE: Evidence and Bayesian Probability

LINKS:
A Bayesian Primer
Bayesian Reasoning
Bayes' Theorem and the Law
DNA Evidence and False Positives

Forensics and Statistics

TOPIC: Drug Analysis

LECTURE: Extraction, Characterization and Isolation

  • Drug Scheduling : Bell, pages 213-227
  • Drug Chemistry: Bell, pages 267-272
  • Chemical Solubility : Bell, pages 92-101
  • Liquid-Liquid extraction : Bell, pages 102-107
  • Solid-Liquid extraction : Bell, pages 108-11; 116-120; 337-342
             

LECTURE: Presumptive Tests

  • Light & Color: Bell, pages 271-280
  • UV/Vis Spectroscopy: Bell, pages 149-162
  • Marquis test: Bell, pages 282-283
  • Scott test : Bell, pages 289-293
             

LECTURE: Characterization by GC-MS

  • GC and MS: Bell, pages 194-203
  • Mass Spectra : Bell, pages 351-352
  • Gas Chromatographs : Bell, pages 236-237; 438-439
             

CASE STUDY I : "Drugs on Money", Anal. Chem., June 1, 2000; pp. 397 A-403 A

LINKS:Drugs
Forensic Toxicology

Lycaeum
TextI

DrugDatabsae
Animated GC Movie

HPLC
Electrophoresis
MS for the Novice
GC/MS For Chromatographers
Animated GC/MS Movie
Mass Spec Tutorial

TOPIC: Statistics I

LECTURE: Basic Concepts

  • Data: Quality & Certainty : Bell, pages 15-27
  • Hypothesis : G test and t test Bell, pages 27-35
             

LINKS:


Neutron Activation Analysis
JFK Assassination Video
JFK Assassination Files

Forensics and Statistics

TOPIC: Forensic Toxicology

LECTURE: Basic Concepts

  • An Overview of Pharmacology : Bell, Chapter 6, pages 239-262

PRESENTATION OUTLINE

  • Toxicology; including physical, chemical and spectroscopic properties
  • Pathology
  • Pharmacodynamics; icluding affected biochemical pathways
  • Pharmacokinetics; including metabolism and cross-tolerance
  • Forensics; including origin, delivery and detection
  • Treatment

 

TOPIC
STUDENT
DATE
Ethylene Glycol, Methanol and Isopropanol
Hindi A.
Monday, Apr. 23
Arsenic and Arsenates
Meredith M. .
Monday April 23
Diquat and Paraquat
Melody R..
Wednesday, Apr. 25
Phenobarbital and Barbiturates
Chris M..
Wednesday, Apr 25
Crotalid, Elapid and Snake Venoms
Sarahi E.
Friday, Apr 27
Strychnine
Victor J.
Friday, Apr. 27
Atropine & Scopolamine
Guadalupe A.
Monday, Apr 30
DDT and Hexachlorophene
Amanda O.
Monday Apr 30
Parathion and Organophosphates
Vincente B..
Wednesday, May 2
Sulfides
Muscarine & Coprine
PCP and Ketamine
Saxitoxin, Tetradotoxins and Batrachotoxins
Morphine & Synthetic Opiates
Salicylic Acid and Salicylates
Amitriptyline and Tricyclics
Lead
Mercury
Caffeine & the Methylxanthines
Cardiac Glycosides

 

CASE STUDY I : CASE STUDY I : "False Cyanide Detection", Anal. Chem., March 1, 2002 / volume 74, issue 5 /pp 134 A-141 A ; "Arsenic Speciation", Anal. Chem., Volume 76, Issue 1
pp 1 A–40 A.

LINKS:
Forensic Toxicology

Lycaeum
TextI

TOPIC: DNA : Profiling and Fingerprinting

LECTURE: DNA Basic Concepts

LECTURE: DNA testing

LECTURE: STRs and Population Analysis

  • Restriction Fragment Length Polymorphism analysis
  • Variable Number Tandem Repeat analysis
  • Short Tandem Repeat analysis
  • Mitochondrial DNA analysis
  • Population genetics and Hardy-Weinberg equilibrium
  • Allele frequency and the CODIS database
  • Power of Discrimination & Power of Exclusion

CASE STUDY I : "The Forensic Community’s Response to September 11", Anal. Chem., April 1, 2002 / volume 74, issue 7 / pp 190 A-195 A

LINKS:
DNA From the Beginning
PCR Graphic
RFLP Analysis
Forensic DNA
TextI

TOPIC: Statistics II

LECTURE: Calibration

  • Regression Analysis : Bell, pages 74-81
  • GC-MS & HPLC
             

LINKS:


Neutron Activation Analysis
JFK Assassination Video
JFK Assassination Files

Forensics and Statistics

TOPIC: Combustion and Explosion

LECTURE: Arson and Explosives

  • Thermodynaics and Kinetics of Combustion : Bell, pages 384--407
  • Arson Investigation Bell, pages 432-440.
  • Detonation and Explosion : Bell, pages 413--428
  • Explosives Bell, pages 448-457.

CASE STUDY I : "A Detection of Explosives by Electronic Noses.", Anal. Chem., Volume 75, Issue 5
pp 81 A–128 A ; "Chemical Analysis of Arson Debris", Anal. Chem., Volume 68 (1996),
pp 541A

LINKS:
Arson

Explosives

Federal Explosives Law
TextI

TextII