department of chemistry and biochemistry
 

CHEM4341 : Forensic Chemistry

 

Dr. Eamonn F. Healy

 


Forensic Journals:

  • Forensic Jounals : a comprehemsive listing
  • Click Here for instructions for browsing and searching the Journal of Forensic Sciences

 

TOPIC: Evidence and Bayesian Probability

LECTURE: Evidence and Bayesian Probability

LINKS: The Monty Hall Problem
A Bayesian Primer
Bayes' Theorem and the Law
DNA Evidence and False Positives

Forensics and Statistics

 

TOPIC: Drug Analysis

LECTURE: Extraction, Characterization and Isolation

  • Drug Scheduling : Bell, pages 213-227
  • Drug Chemistry: Bell, pages 267-272
  • Chemical Solubility : Bell, pages 92-101
  • Liquid-Liquid extraction : Bell, pages 102-107
  • Solid-Liquid extraction : Bell, pages 108-11; 116-120; 337-342
             

LECTURE: Presumptive Tests

  • Light & Color: Bell, pages 271-280
  • UV/Vis Spectroscopy: Bell, pages 149-162
  • Marquis test: Bell, pages 282-283
  • Scott test : Bell, pages 289-293
             

LECTURE: Characterization by GC-MS

  • GC and MS: Bell, pages 194-203
  • Mass Spectra : Bell, pages 351-352
  • Gas Chromatographs : Bell, pages 236-237; 438-439
             

CASE STUDY : "Drugs on Money", Anal. Chem., June 1, 2000; pp. 397 A-403 A

LINKS:

  • GC-MS & HPLC
             
  • TOPIC: Statistics I

    LECTURE: Basic Concepts

    • Data: Quality & Certainty : Bell, pages 15-27
    • Hypothesis : G test and t test Bell, pages 27-35
               

    LINKS:

     

    TOPIC: Forensic Toxicology

    LECTURE: Basic Concepts

    • An Overview of Pharmacology : Bell, Chapter 6, pages 239-262

    PRESENTATION OUTLINE

    • Toxicology; including physical, chemical and spectroscopic properties
    • Pathology
    • Pharmacodynamics; icluding affected biochemical pathways
    • Pharmacokinetics; including metabolism and cross-tolerance
    • Forensics; including origin, delivery and detection
    • Treatment

     

    TOPIC
    STUDENT
    DATE
    Ethylene Glycol, Methanol and Isopropanol
     
    Arsenic and Arsenates
     
    Diquat and Paraquat
     
    Phenobarbital and Barbiturates
     
    Crotalid, Elapid and Snake Venoms
     
    Strychnine
     
    Atropine & Scopolamine
     
    DDT and Hexachlorophene
     
    Parathion and Organophosphates
     
    Sulfides
     
    Muscarine & Coprine
     
    PCP and Ketamine
     
    Saxitoxin, Tetradotoxins and Batrachotoxins
    Morphine & Synthetic Opiates
    Salicylic Acid and Salicylates
    Amitriptyline and Tricyclics
    Lead
    Mercury
    Caffeine & the Methylxanthines
    Cardiac Glycosides

     

    CASE STUDY : "False Cyanide Detection", Anal. Chem., March 1, 2002 / volume 74, issue 5 /pp 134 A-141 A ; "Arsenic Speciation", Anal. Chem., Volume 76, Issue 1
    pp 1 A–40 A.

     

    TOPIC: DNA : Profiling and Fingerprinting

    LECTURE: DNA Basic Concepts

    LECTURE: DNA testing

    LECTURE: STRs and Population Analysis

    • Restriction Fragment Length Polymorphism analysis
    • Variable Number Tandem Repeat analysis
    • Short Tandem Repeat analysis
    • Mitochondrial DNA analysis
    • Population genetics and Hardy-Weinberg equilibrium
    • Allele frequency and the CODIS database
    • Power of Discrimination & Power of Exclusion

    CASE STUDY : "The Forensic Community’s Response to September 11", Anal. Chem., April 1, 2002 / volume 74, issue 7 / pp 190 A-195 A

    TOPIC: Statistics II

    LECTURE: Calibration

    TOPIC: Combustion and Explosion

    LECTURE: Arson and Explosives

    • Thermodynaics and Kinetics of Combustion : Bell, pages 384--407
    • Arson Investigation Bell, pages 432-440.
    • Detonation and Explosion : Bell, pages 413--428
    • Explosives Bell, pages 448-457.

    CASE STUDY : "A Detection of Explosives by Electronic Noses.", Anal. Chem., Volume 75, Issue 5
    pp 81 A–128 A ; "Chemical Analysis of Arson Debris", Anal. Chem., Volume 68 (1996),
    pp 541A