Professor of Chemistry
Office: JBWN 215
SEU Box: 805 e-mail : email@example.com
Phone: (512) 448-8467
University College Cork, Ireland, 1976-1980 B.S. Chemistry.
University of Texas at Austin, 1980-1984 Ph.D. Chemistry.
The general focus of our research involves the use of molecular modeling to design structure-activity probes for the purpose of elucidating enzymatic activity. Recent targets have included HIV-1 integrase, the c-Kit and src-abl proteins associated with tumor development and certain leukemias, and the metalloproteinases associated with the shedding of chemokine CXCL16. We have also developed in silico characterizations of the mechanism of action of the Mtb alpha-crystallin protein, and models for the heat shock response of Escherichia coli and for the observed suppression of spinocerebellar ataxia by human alphaB-crystallin. A transient, non-obligate oligomer model has also been developed to explain aspects of the etiology of Amyotrophic Lateral Sclerosis or ALS.A more detailed description of this research can be be viewed at the link shown to the right.
A full listing of my courses, with syllabi and class materials, can be viewed at the link shown to the right.
Eamonn F Healy, Luis Cervantes†, Barret Nabona†, Jacob Williams†, A unified mechanism for plant polyketide biosynthesis derived from in silico modeling, Biochemical and Biophysical Research Communications, 2018,497, 1123-1128. . doi: 10.1016/j.bbrc.2018.02.190
E.F. Healy, “Visualizing the molecular wave function in sigma-coordinated complexes”, Computational and Theoretical Chemistr, ,2018, 1125, 128-132. doi:10.1016/j.comptc.2018.01.010 [for an account see Science Trends]
Eamonn F. Healy “A prion-like mechanism for the propagated misfolding of SOD1 ”, PLoS ONE 2017,12 (5), e0177284. doi:10.1371/journal.pone.0177284
Eamonn F. Healy “A mechanism for propagated SOD1 misfolding from frustration analysis of a G85R mutant protein assembly”, Biochem. Biophys. Res. Commun. 2016, 478, 1634-1639. doi: 10.1016/j.bbrc.2016.08.172.
Eamonn F. Healy and Luis Cervantes† “An in silico study of the effect of SOD1 electrostatic loop dynamics on amyloid-like filament formation ”, Euro. Biophys. J. 2016, 45, 853-859. 10.1007/s00249-016-1163-9
Eamonn F. Healy “A role for non-obligate oligomer formation in protein aggregation”, Biochem. Biophys. Res. Commun. 2015, 465 , 523-527. doi: 10.1016/j.bbrc.2015.08.052.
Eamonn F. Healy, Carley Little† and Peter J. King “A model for small heat shock protein inhibition of polyglutamine aggregation”, Cell Biochem. Biophys. 2014, 69, 275-281.doi: 10.1007/s12013-013-9795-1 .
Eamonn F. Healy “Michael J. S. Dewar: A Model Iconoclast” In Pioneers of Quantum Chemistry, E. Thomas Strom, Angela K. Wilson , Eds. , ACS Symposium Series, Vol. 1122; American Chemical Society: Washington, DC, 2013 pp 139–153. doi: 10.1021/bk-2013-1122.ch005 .
Eamonn F. Healy, "A model for heterooligomer formation in the heat shock response of E. coli.", Biochem. Biophys. Res. Commun., 2012, 420, 639-643.doi: 10.1016/j.bbrc.2012.03.054.
Eamonn F. Healy, and Peter J. King "A Mechanism of Action for Small Heat Shock Proteins" , Biochem. Biophys. Res. Commun., 2012, 417, 268–273. doi:10.1016/j.bbrc.2011.11.098.
E.F. Healy, “Heisenberg's Chemical Legacy: Resonance and the Chemical Bond”, Foundations of Chemistry, 2011, 13, 39-49;doi: 10.1007/s10698-011-9104-2 .
E.F. Healy, “The effect of desolvation on nucleophilic halogenase activity”, Computational and Theoretical Chemistry, 2011, 964, 91-93; doi: 10.1016/j.comptc.2010.12.003.
Eamonn F. Healy, Pablo Romano†, Moises Mejia† and Gunnar Lindfors III†, Acetylenic Inhibitors of ADAM10 and ADAM17: In silico analysis of potency and selectivity J. Mol. Graph. Model.,2010, 29, 436-442; doi:10.1016/j.jmgm.2010.08.006.
Eamonn F. Healy, Samuel Manzer, Jeffrey Gorman, Alicia Jones† and Nicholas Cristea† "A dramatic heavy atom effect in the quenching of dichlorosubstituted lucigenin fluorescence", Chem. Phys. Lett., 2010, 485 , 258-261; doi:10.1016/j.cplett.2009.12.049.
E.F. Healy “In Defense of a Heuristic Interpretation of Quantum Mechanics”, J. Chem. Educ., 2010, 87 , 559-563; doi: 10.1021/ed8001545.
† student author
A complete list of publications is also available, with the full text for many of these articles available for download at ResearchGate.
Recent Professional Presentations
"Structural Ontology and Chemical Epistemology:The case of the pi-complex" Eamonn F Healy, presented at the International Society for the Philosophy of Chemistry - Summer Symposium , Boca Raton, 2016.
PAPER HIST 22 , "Between two stools: Pauling, Mulliken, and Michael J. S. Dewar" Eamonn F Healy, presented at the 251st ACS National Meeting & Exposition, San Diego, Spring, 2016. [for an account see C&E News]
Cienega, L*., & Healy, E. F. (2014, March). Rational design for matrix metalloproteinase (MMP-1). In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 247). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Bui, A.*, & Healy, E. F. (2014, March). Modeling the conformational flexibility of resveratrol. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 247). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Little, C.*, & Healy, E. (2013, April). Model for small heat shock protein inhibition of polyglutamine aggregation. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 245). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Petty, C. N.*, Healy, E. F., & King, P. (2013, April). Resveratrol and resveratrol derivatives as class IA PI3K inhibitors. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 245). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Paper COMP 193 “Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl ”,Eamonn F Healy, presented at the 244th National Meeting of the American Chemical Society in Philadelpha, Fall 2012.
Paper CHED 360 “Acetylenic inhibitors of ADAM10 and ADAM17: In silico analysis of potency and selectivity”, Pablo G Romano *, Moises Mejia* , Eamonn F Healy, presented at the 243rd National Meeting of the American Chemical Society in San Diego, Spring 2012.
Presenters are underlined; undergraduate student authors are noted by asterisks.